From March 10, 2017 15:00 until March 10, 2017 16:00
Posted by Renee Bennett
Categories: CCAM Seminar
Dr. Marcelo Tolmasky (CSU Fullerton) – The Superbugs Are Among Us, Can We Beat Them?
The superbugs are among us. Can we beat them?
Antibiotic resistance has been identified as a major threat to human health. Its rise not only complicates treatment
of infectious diseases but also threatens medical procedures like surgery, transplants or chemotherapy, which
depend on prevention of infection. Several pathogens have become resistant to many different antibiotics and in
some cases they are virtually untreatable. While in the past when one antibiotic became ineffective there was
always a newer one that was, in the present times the number of new antibiotics in development is dangerously
low. We have designed our research project to combat the growing problem of antibiotic resistance by prolonging
the effectiveness of currently available antibiotics. In particular we concentrate on antibiotics of the family of
aminoglycosides. We have determined the most clinically relevant mechanism of resistance to the amikacin and
other related antibiotics, and how the gene coding for resistance disseminates. We are researching strategies to
design adjuvants that when administered in combination with amikacin circumvent the resistance, restoring the
effectiveness to the treatment.